Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cannavo, Alessandro, Liccardo, Daniela, Eguchi, Akito, Elliott, Katherine J., Traynham, Christopher J., Ibetti, Jessica, Eguchi, Satoru, Leosco, Dario, Ferrara, Nicola, Rengo, Giuseppe, Koch, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778065/
https://ncbi.nlm.nih.gov/pubmed/26932512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10877
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