Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardi...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Cannavo, Alessandro, Liccardo, Daniela, Eguchi, Akito, Elliott, Katherine J., Traynham, Christopher J., Ibetti, Jessica, Eguchi, Satoru, Leosco, Dario, Ferrara, Nicola, Rengo, Giuseppe, Koch, Walter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778065/
https://ncbi.nlm.nih.gov/pubmed/26932512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10877
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