Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA

The well known biomarker of oxidative stress, 8-oxo-7,8-dihydroguanine, is more susceptible to further oxidation than the parent guanine base and can be oxidatively transformed to the genotoxic spiroiminodihydantoin (Sp) and 5-guanidinohydantoin (Gh) lesions. Incubation of 135-mer duplexes with sing...

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Vydáno v:J Biol Chem
Hlavní autoři: Shafirovich, Vladimir, Kropachev, Konstantin, Anderson, Thomas, Liu, Zhi, Kolbanovskiy, Marina, Martin, Brooke D., Sugden, Kent, Shim, Yoonjung, Chen, Xuejing, Min, Jung-Hyun, Geacintov, Nicholas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777862/
https://ncbi.nlm.nih.gov/pubmed/26733197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.693218
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