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Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases

Bacterial l-asparaginases play an important role in the treatment of certain types of blood cancers. We are exploring the guinea pig l-asparaginase (gpASNase1) as a potential replacement of the immunogenic bacterial enzymes. The exact mechanism used by l-asparaginases to catalyze the hydrolysis of a...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Schalk, Amanda M., Antansijevic, Aleksandar, Caffrey, Michael, Lavie, Arnon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777844/
https://ncbi.nlm.nih.gov/pubmed/26733195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699884
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