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Identification and Structural Analysis of an l-Asparaginase Enzyme from Guinea Pig with Putative Tumor Cell Killing Properties

The initial observation that guinea pig serum kills lymphoma cells marks the serendipitous discovery of a new class of anti-cancer agents. The serum cell killing factor was shown to be an enzyme with l-asparaginase (ASNase) activity. As a direct result of this observation, several bacterial l-aspara...

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Pubblicato in:J Biol Chem
Autori principali: Schalk, Amanda M., Nguyen, Hien-Anh, Rigouin, Coraline, Lavie, Arnon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246078/
https://ncbi.nlm.nih.gov/pubmed/25320094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609552
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