Glu-311 in External Loop 4 of the Sodium/Proline Transporter PutP Is Crucial for External Gate Closure

The available structural information on LeuT and structurally related transporters suggests that external loop 4 (eL4) and the outer end of transmembrane domain (TM) 10′ participate in the reversible occlusion of the outer pathway to the solute binding sites. Here, the functional significance of eL4...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Bracher, Susanne, Guérin, Kamila, Polyhach, Yevhen, Jeschke, Gunnar, Dittmer, Sophie, Frey, Sabine, Böhm, Maret, Jung, Heinrich
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Membrane Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777837/
https://ncbi.nlm.nih.gov/pubmed/26728461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675306
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