Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs

The ability of inositol 1,4,5-trisphosphate receptors (IP(3)R) to precisely initiate and generate a diverse variety of intracellular Ca(2+) signals is in part mediated by the differential regulation of the three subtypes (R1, R2, and R3) by key functional modulators (IP(3), Ca(2+), and ATP). However...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Chandrasekhar, Rahul, Alzayady, Kamil J., Wagner, Larry E., Yule, David I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777821/
https://ncbi.nlm.nih.gov/pubmed/26755721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705301
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