Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors

BACKGROUND: Impaired cardiac function in doxorubicin-treated childhood cancer survivors is partly mediated by disruption of mitochondrial energy production. Doxorubicin intercalates into mitochondrial DNA (mtDNA) disrupting genes encoding for polypeptides that make ATP. METHODS: This cross-sectional...

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Udgivet i:Cancer
Main Authors: Lipshultz, Steven E., Anderson, Lynn M., Miller, Tracie L., Gerschenson, Mariana, Stevenson, Kristen E., Neuberg, Donna S., Franco, Vivian I., LiButti, Daniel E., Silverman, Lewis B., Vrooman, Lynda M., Sallan, Stephen E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777628/
https://ncbi.nlm.nih.gov/pubmed/26762648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29872
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