Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors

BACKGROUND: Impaired cardiac function in doxorubicin-treated childhood cancer survivors is partly mediated by disruption of mitochondrial energy production. Doxorubicin intercalates into mitochondrial DNA (mtDNA) disrupting genes encoding for polypeptides that make ATP. METHODS: This cross-sectional...

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Dades bibliogràfiques
Publicat a:Cancer
Autors principals: Lipshultz, Steven E., Anderson, Lynn M., Miller, Tracie L., Gerschenson, Mariana, Stevenson, Kristen E., Neuberg, Donna S., Franco, Vivian I., LiButti, Daniel E., Silverman, Lewis B., Vrooman, Lynda M., Sallan, Stephen E.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777628/
https://ncbi.nlm.nih.gov/pubmed/26762648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29872
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