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Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication

Allostery is one of the pervasive mechanisms through which proteins in living systems carry out enzymatic activity, cell signaling, and metabolism control. Effective modeling of the protein function regulation requires a synthesis of the thermodynamic and structural views of allostery. We present he...

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Publicat a:PLoS Comput Biol
Autors principals: Guarnera, Enrico, Berezovsky, Igor N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777440/
https://ncbi.nlm.nih.gov/pubmed/26939022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004678
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