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Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication

Allostery is one of the pervasive mechanisms through which proteins in living systems carry out enzymatic activity, cell signaling, and metabolism control. Effective modeling of the protein function regulation requires a synthesis of the thermodynamic and structural views of allostery. We present he...

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Библиографические подробности
Опубликовано в: :PLoS Comput Biol
Главные авторы: Guarnera, Enrico, Berezovsky, Igor N.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777440/
https://ncbi.nlm.nih.gov/pubmed/26939022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004678
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