Development of Selective Covalent Janus Kinase 3 Inhibitors

The Janus Kinases (JAKs) and their downstream effectors Signal Transducer and Activator of Transcription proteins (STATs) form a critical immune cell signaling circuit, which is of fundamental importance in innate immunity, inflammation and hematopoiesis and dysregulation is frequently observed in i...

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Vydáno v:J Med Chem
Hlavní autoři: Tan, Li, Akahane, Koshi, McNally, Randall, Reyskens, Kathleen M. S. E., Ficarro, Scott B., Liu, Suhu, Herter-Sprie, Grit S., Koyama, Shohei, Pattison, Michael J., Labella, Katherine, Johannessen, Liv, Akbay, Esra A., Wong, Kwok-Kin, Frank, David A., Marto, Jarrod A., Look, Thomas A., Arthur, J. Simon C., Eck, Michael J., Gray, Nathanael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777322/
https://ncbi.nlm.nih.gov/pubmed/26258521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00710
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