Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

OBJECTIVES: Adjunctive host-directed therapy is emerging as a new potential approach to improve the outcome of conventional antimicrobial treatment for tuberculosis (TB). We tested the ability of a phosphodiesterase-4 inhibitor (PDE4i) CC-11050, co-administered with the first-line anti-TB drug isoni...

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Vydáno v:EBioMedicine
Hlavní autoři: Subbian, Selvakumar, Tsenova, Liana, Holloway, Jennifer, Peixoto, Blas, O'Brien, Paul, Dartois, Véronique, Khetani, Vikram, Zeldis, Jerome B., Kaplan, Gilla
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776074/
https://ncbi.nlm.nih.gov/pubmed/26981575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.01.015
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