Sequential Evolution of Vancomycin-Intermediate Resistance Alters Virulence in Staphylococcus aureus: Pharmacokinetic/Pharmacodynamic Targets for Vancomycin Exposure

Staphylococcus aureus possesses exceptional virulence and a remarkable ability to adapt in the face of antibiotic therapy. We examined the in vitro evolution of S. aureus in response to escalating vancomycin exposure by evaluating bacterial killing and the progression of resistance. A hollow-fiber i...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Lenhard, Justin R., Brown, Tanya, Rybak, Michael J., Meaney, Calvin J., Norgard, Nicholas B., Bulman, Zackery P., Brazeau, Daniel A., Gill, Steven R., Tsuji, Brian T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776009/
https://ncbi.nlm.nih.gov/pubmed/26711763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02657-15
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