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Sequential Evolution of Vancomycin-Intermediate Resistance Alters Virulence in Staphylococcus aureus: Pharmacokinetic/Pharmacodynamic Targets for Vancomycin Exposure

Staphylococcus aureus possesses exceptional virulence and a remarkable ability to adapt in the face of antibiotic therapy. We examined the in vitro evolution of S. aureus in response to escalating vancomycin exposure by evaluating bacterial killing and the progression of resistance. A hollow-fiber i...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Lenhard, Justin R., Brown, Tanya, Rybak, Michael J., Meaney, Calvin J., Norgard, Nicholas B., Bulman, Zackery P., Brazeau, Daniel A., Gill, Steven R., Tsuji, Brian T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776009/
https://ncbi.nlm.nih.gov/pubmed/26711763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02657-15
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