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Ceftaroline Increases Membrane Binding and Enhances the Activity of Daptomycin against Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus in a Pharmacokinetic/Pharmacodynamic Model

New antimicrobial agents and novel combination therapies are needed to treat serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA) with reduced susceptibility to daptomycin and vancomycin. The purpose of this study was to evaluate the combination of ceftaroline plus daptomy...

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Detalhes bibliográficos
Main Authors: Werth, Brian J., Sakoulas, George, Rose, Warren E., Pogliano, Joseph, Tewhey, Ryan, Rybak, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535972/
https://ncbi.nlm.nih.gov/pubmed/23070161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01586-12
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