Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques

We evaluated the in vivo pharmacokinetics and used a complementary ex vivo coculture assay to determine the pharmacodynamics of IQB3002 gel containing 1% IQP-0528, a nonnucleoside reverse transcriptase inhibitor (NNRTI), in rhesus macaques (RM). The gel (1.5 ml) was applied vaginally to 6 simian-hum...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Pereira, Lara E., Mesquita, Pedro M. M., Ham, Anthony, Singletary, Tyana, Deyounks, Frank, Martin, Amy, McNicholl, Janet, Buckheit, Karen W., Buckheit, Robert W., Smith, James M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775942/
https://ncbi.nlm.nih.gov/pubmed/26666935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02201-15
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