Effects of gel volume on pharmacokinetics for vaginal and rectal applications of combination DuoGel-IQB4012, a dual chamber-dual drug HIV microbicide gel, in pigtailed macaques

This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal gel volumes (1% loading of both drugs) were 0.5 o...

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Опубликовано в: :Drug Deliv Transl Res
Главные авторы: Pereira, Lara E., Singletary, Tyana, Martin, Amy, Dinh, Chuong T., Deyounks, Frank, Holder, Angela, McNicholl, Janet, Buckheit, Karen W., Buckheit, Robert W., Ham, Anthony, Katz, David F., Smith, James M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711467/
https://ncbi.nlm.nih.gov/pubmed/29761350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-018-0538-0
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