Vaginal Microbicide Gel for Delivery of IQP-0528, a Pyrimidinedione Analog with a Dual Mechanism of Action against HIV-1

Pyrimidinediones, a novel class of compounds, have previously been shown to possess antiviral activity at nanomolar concentrations. One member of this class of compounds, IQP-0528, was selected as the lead molecule for formulation development owing to its stability at physiologically relevant condit...

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Main Authors: Mahalingam, Alamelu, Simmons, Adam P., Ugaonkar, Shweta R., Watson, Karen M., Dezzutti, Charlene S., Rohan, Lisa C., Buckheit, Robert W., Kiser, Patrick F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067148/
https://ncbi.nlm.nih.gov/pubmed/21245437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01368-10
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