SAR405838: A novel and potent inhibitor of the MDM2:p53 axis for the treatment of dedifferentiated liposarcoma

PURPOSE: Dedifferentiated liposarcoma (DDLPS) is an aggressive malignancy that can recur locally or disseminate even after multidisciplinary care. Genetically amplified and expressed MDM2, often referred to as a “hallmark” of DDLPS, mostly sustains a wild-type p53 genotype, substantiating the p53-MD...

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Udgivet i:Clin Cancer Res
Main Authors: Bill, Kate Lynn J., Garnett, Jeannine, Meaux, Isabelle, Ma, XiaoYen, Creighton, Chad J., Bolshakov, Svetlana, Barriere, Cedric, Debussche, Laurent, Lazar, Alexander J., Prudner, Bethany C., Casadei, Lucia, Braggio, Danielle, Lopez, Gonzalo, Zewdu, Abbie, Bid, Hemant, Lev, Dina, Pollock, Raphael E.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775372/
https://ncbi.nlm.nih.gov/pubmed/26475335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1522
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