MDM2 derived from dedifferentiated liposarcoma extracellular vesicles induces MMP2 production from preadipocytes

Dedifferentiated liposarcoma (DDLPS) is frequently diagnosed late and patients typically respond poorly to treatments. DDLPS is molecularly characterized by wild-type p53 and amplification of the MDM2 gene which results in overexpression of MDM2 protein, a key oncogenic process in DDLPS. In this stu...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Casadei, Lucia, Calore, Federica, Braggio, Danielle A., Zewdu, Abeba, Deshmukh, Ameya A., Fadda, Paolo, Lopez, Gonzalo, Wabitsch, Martin, Song, Chi, Leight, Jennifer L., Grignol, Valerie P., Lev, Dina, Croce, Carlo M., Pollock, Raphael E.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774856/
https://ncbi.nlm.nih.gov/pubmed/31387924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0203
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