SAR405838: A novel and potent inhibitor of the MDM2:p53 axis for the treatment of dedifferentiated liposarcoma

PURPOSE: Dedifferentiated liposarcoma (DDLPS) is an aggressive malignancy that can recur locally or disseminate even after multidisciplinary care. Genetically amplified and expressed MDM2, often referred to as a “hallmark” of DDLPS, mostly sustains a wild-type p53 genotype, substantiating the p53-MD...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Bill, Kate Lynn J., Garnett, Jeannine, Meaux, Isabelle, Ma, XiaoYen, Creighton, Chad J., Bolshakov, Svetlana, Barriere, Cedric, Debussche, Laurent, Lazar, Alexander J., Prudner, Bethany C., Casadei, Lucia, Braggio, Danielle, Lopez, Gonzalo, Zewdu, Abbie, Bid, Hemant, Lev, Dina, Pollock, Raphael E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775372/
https://ncbi.nlm.nih.gov/pubmed/26475335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1522
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