Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neurobla...

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Publicado no:Nat Genet
Main Authors: Eleveld, Thomas F., Oldridge, Derek A., Bernard, Virginie, Koster, Jan, Daage, Leo Colmet, Diskin, Sharon J., Schild, Linda, Bentahar, Nadia Bessoltane, Bellini, Angela, Chicard, Mathieu, Lapouble, Eve, Combaret, Valérie, Legoix-Né, Patricia, Michon, Jean, Pugh, Trevor J., Hart, Lori S., Rader, JulieAnn, Attiyeh, Edward F., Wei, Jun S., Zhang, Shile, Naranjo, Arlene, Gastier-Foster, Julie M., Hogarty, Michael D., Asgharzadeh, Shahab, Smith, Malcolm A., Guidry Auvil, Jaime M., Watkins, Thomas B. K., Zwijnenburg, Danny A., Ebus, Marli E., van Sluis, Peter, Hakkert, Anne, van Wezel, Esther, van der Schoot, C. Ellen, Westerhout, Ellen M., Schulte, Johannes H., Tytgat, Godelieve A., Dolman, M. Emmy M., Janoueix-Lerosey, Isabelle, Gerhard, Daniela S., Caron, Huib N., Delattre, Olivier, Khan, Javed, Versteeg, Rogier, Schleiermacher, Gudrun, Molenaar, Jan J., Maris, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775079/
https://ncbi.nlm.nih.gov/pubmed/26121087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3333
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