Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

The POU4F2/Brn-3b transcription factor has been identified as a potentially novel regulator of key metabolic processes. Loss of this protein in Brn-3b knockout (KO) mice causes profound hyperglycemia and insulin resistance (IR), normally associated with type 2 diabetes (T2D), whereas Brn-3b is reduc...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Endocrinol Metab
Hoofdauteurs: Bitsi, Stavroula, Ali, Houda, Maskell, Lauren, Ounzain, Samir, Mohamed-Ali, Vidya, Budhram-Mahadeo, Vishwanie S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773651/
https://ncbi.nlm.nih.gov/pubmed/26670484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00211.2015
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