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Comparison of the aggregation of homologous β(2)-microglobulin variants reveals protein solubility as a key determinant of amyloid formation
The mouse and human β(2)-microglobulin protein orthologs are 70 % identical in sequence and share 88 % sequence similarity. These proteins are predicted by various algorithms to have similar aggregation and amyloid propensities. However, whilst human β(2)m (hβ(2)m) forms amyloid-like fibrils in dena...
Gardado en:
| Publicado en: | J Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4773402/ https://ncbi.nlm.nih.gov/pubmed/26780548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.01.009 |
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