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Glimpses of the molecular mechanisms of β(2)-microglobulin fibril formation in vitro: Aggregation on a complex energy landscape

β(2)-microglobulin (β(2)m) is a 99-residue protein that aggregates to form amyloid fibrils in dialysis-related amyloidosis. The protein provides a powerful model for exploration of the structural molecular mechanisms of fibril formation from a full-length protein in vitro. Fibrils have been assemble...

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Hlavní autoři: Platt, Geoffrey W., Radford, Sheena E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science B.V 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734061/
https://ncbi.nlm.nih.gov/pubmed/19433089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.05.005
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