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Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta

Activation of the wnt signaling pathway is a major cause of colon cancer development. Tankyrase inhibitors (TNKSi) have recently been developed to block the wnt pathway by increasing axin levels to promote degradation of the wnt-regulator β-catenin. TNKSi bind to the PARP (poly(ADP)ribose polymerase...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Martino-Echarri, Estefania, Brocardo, Mariana G., Mills, Kate M., Henderson, Beric R.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773256/
https://ncbi.nlm.nih.gov/pubmed/26930278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150484
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