Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta

Activation of the wnt signaling pathway is a major cause of colon cancer development. Tankyrase inhibitors (TNKSi) have recently been developed to block the wnt pathway by increasing axin levels to promote degradation of the wnt-regulator β-catenin. TNKSi bind to the PARP (poly(ADP)ribose polymerase...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Martino-Echarri, Estefania, Brocardo, Mariana G., Mills, Kate M., Henderson, Beric R.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773256/
https://ncbi.nlm.nih.gov/pubmed/26930278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150484
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