Inhibitors of Streptococcus pneumoniae Surface Endonuclease EndA Discovered by High-Throughput Screening Using a PicoGreen Fluorescence Assay

The human commensal pathogen, Streptococcus pneumoniae, expresses a number of virulence factors that promote serious pneumococcal diseases, resulting in significant morbidity and mortality worldwide. These virulence factors may give S. pneumoniae the capacity to escape immune defenses, resist antimi...

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Pubblicato in:J Biomol Screen
Autori principali: Peterson, Eliza J.R., Kireev, Dmitri, Moon, Andrea F., Midon, Marika, Janzen, William P., Pingoud, Alfred, Pedersen, Lars C., Singleton, Scott F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773034/
https://ncbi.nlm.nih.gov/pubmed/23015019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112461153
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