Therapeutic potential of targeting microRNA‐10b in established intracranial glioblastoma: first steps toward the clinic

MicroRNA‐10b (miR‐10b) is a unique oncogenic miRNA that is highly expressed in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR‐10b inhibition strongly impairs proliferation and survival of cultured glioma cells, including glioma‐initiating stem‐like cells (GSC). Although...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Teplyuk, Nadiya M, Uhlmann, Erik J, Gabriely, Galina, Volfovsky, Natalia, Wang, Yang, Teng, Jian, Karmali, Priya, Marcusson, Eric, Peter, Merlene, Mohan, Athul, Kraytsberg, Yevgenya, Cialic, Ron, Chiocca, E Antonio, Godlewski, Jakub, Tannous, Bakhos, Krichevsky, Anna M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772951/
https://ncbi.nlm.nih.gov/pubmed/26881967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505495
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