Therapeutic potential of targeting microRNA‐10b in established intracranial glioblastoma: first steps toward the clinic

MicroRNA‐10b (miR‐10b) is a unique oncogenic miRNA that is highly expressed in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR‐10b inhibition strongly impairs proliferation and survival of cultured glioma cells, including glioma‐initiating stem‐like cells (GSC). Although...

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Enregistré dans:
Détails bibliographiques
Publié dans:EMBO Mol Med
Auteurs principaux: Teplyuk, Nadiya M, Uhlmann, Erik J, Gabriely, Galina, Volfovsky, Natalia, Wang, Yang, Teng, Jian, Karmali, Priya, Marcusson, Eric, Peter, Merlene, Mohan, Athul, Kraytsberg, Yevgenya, Cialic, Ron, Chiocca, E Antonio, Godlewski, Jakub, Tannous, Bakhos, Krichevsky, Anna M
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772951/
https://ncbi.nlm.nih.gov/pubmed/26881967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505495
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