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OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiquitination...
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| 發表在: | EMBO Mol Med |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
John Wiley and Sons Inc.
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4772950/ https://ncbi.nlm.nih.gov/pubmed/26881969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505972 |
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