The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling

Inappropriate activation of epidermal growth factor receptor (EGFR) plays a causal role in many cancers including colon cancer. The activation of EGFR by phosphorylation is balanced by receptor kinase and protein tyrosine phosphatase activities. However, the mechanisms of negative EGFR regulation by...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Asbagh, Layka Abbasi, Vazquez, Iria, Vecchione, Loredana, Budinska, Eva, De Vriendt, Veerle, Baietti, Maria Francesca, Steklov, Mikhail, Jacobs, Bart, Hoe, Nicholas, Singh, Sharat, Imjeti, Naga-Sailaja, Zimmermann, Pascale, Sablina, Anna, Tejpar, Sabine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259406/
https://ncbi.nlm.nih.gov/pubmed/25301722
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