The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling

Inappropriate activation of epidermal growth factor receptor (EGFR) plays a causal role in many cancers including colon cancer. The activation of EGFR by phosphorylation is balanced by receptor kinase and protein tyrosine phosphatase activities. However, the mechanisms of negative EGFR regulation by...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Asbagh, Layka Abbasi, Vazquez, Iria, Vecchione, Loredana, Budinska, Eva, De Vriendt, Veerle, Baietti, Maria Francesca, Steklov, Mikhail, Jacobs, Bart, Hoe, Nicholas, Singh, Sharat, Imjeti, Naga-Sailaja, Zimmermann, Pascale, Sablina, Anna, Tejpar, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259406/
https://ncbi.nlm.nih.gov/pubmed/25301722
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