Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells

The EGFR inhibitor cetuximab is approved for the treatment of colorectal cancer. However, both innate and acquired resistance mechanisms, including compensatory feedback loops, limit its efficacy. Nevertheless, the emergence of these feedback loops has remained largely unexplored to date. Here, we s...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bosch-Vilaró, Albert, Jacobs, Bart, Pomella, Valentina, Asbagh, Layka Abbasi, Kirkland, Richard, Michel, Joe, Singh, Sharat, Liu, Xinjun, Kim, Phillip, Weitsman, Gregory, Barber, Paul R., Vojnovic, Borivoj, Ng, Tony, Tejpar, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354831/
https://ncbi.nlm.nih.gov/pubmed/28032592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13834
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