OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiquitination...

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Bibliografiske detaljer
Udgivet i:EMBO Mol Med
Main Authors: Baietti, Maria Francesca, Simicek, Michal, Abbasi Asbagh, Layka, Radaelli, Enrico, Lievens, Sam, Crowther, Jonathan, Steklov, Mikhail, Aushev, Vasily N, Martínez García, David, Tavernier, Jan, Sablina, Anna A
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772950/
https://ncbi.nlm.nih.gov/pubmed/26881969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505972
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