Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

The leucine zipper–like transcriptional regulator 1 (LZTR1) protein, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, is implicated in human disease, yet its mechanism of action remains unknown. We found that Lztr1 haploinsufficiency in mice recapitulates Noonan syndrome phenotypes, whereas...

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Published in:Science
Main Authors: Steklov, M., Pandolfi, S., Baietti, M. F., Batiuk, A., Carai, P., Najm, P., Zhang, M., Jang, H., Renzi, F., Cai, Y., Asbagh, L. Abbasi, Pastor, T., De Troyer, M., Simicek, M., Radaelli, E., Brems, H., Legius, E., Tavernier, J., Gevaert, K., Impens, F., Messiaen, L., Nussinov, R., Heymans, S., Eyckerman, S., Sabina, A. A.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058620/
https://ncbi.nlm.nih.gov/pubmed/30442762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aap7607
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