Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo

Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid fibrils, including the amyloid β (Aβ) fibrils in the cerebral parenchyma plaques and cerebrovascular amyloid deposits of Alzheimer's disease (...

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Détails bibliographiques
Publié dans:Open Biol
Auteurs principaux: Al-Shawi, Raya, Tennent, Glenys A., Millar, David J., Richard-Londt, Angela, Brandner, Sebastian, Werring, David J., Simons, J. Paul, Pepys, Mark B.
Format: Artigo
Langue:Inglês
Publié: The Royal Society 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772805/
https://ncbi.nlm.nih.gov/pubmed/26842068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150202
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