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A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

With <2% of the human genome coding for proteins, a major challenge is to interpret the function of the noncoding DNA. Millions of regulatory sequences have been predicted in the human genome through analysis of DNA methylation, chromatin modification, hypersensitivity to nucleases, and transcrip...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Diao, Yarui, Li, Bin, Meng, Zhipeng, Jung, Inkyung, Lee, Ah Young, Dixon, Jesse, Maliskova, Lenka, Guan, Kun-liang, Shen, Yin, Ren, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772021/
https://ncbi.nlm.nih.gov/pubmed/26813977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.197152.115
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