A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

With <2% of the human genome coding for proteins, a major challenge is to interpret the function of the noncoding DNA. Millions of regulatory sequences have been predicted in the human genome through analysis of DNA methylation, chromatin modification, hypersensitivity to nucleases, and transcrip...

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Vydáno v:Genome Res
Hlavní autoři: Diao, Yarui, Li, Bin, Meng, Zhipeng, Jung, Inkyung, Lee, Ah Young, Dixon, Jesse, Maliskova, Lenka, Guan, Kun-liang, Shen, Yin, Ren, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772021/
https://ncbi.nlm.nih.gov/pubmed/26813977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.197152.115
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