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A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

With <2% of the human genome coding for proteins, a major challenge is to interpret the function of the noncoding DNA. Millions of regulatory sequences have been predicted in the human genome through analysis of DNA methylation, chromatin modification, hypersensitivity to nucleases, and transcrip...

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Bibliografiske detaljer
Udgivet i:Genome Res
Main Authors: Diao, Yarui, Li, Bin, Meng, Zhipeng, Jung, Inkyung, Lee, Ah Young, Dixon, Jesse, Maliskova, Lenka, Guan, Kun-liang, Shen, Yin, Ren, Bing
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772021/
https://ncbi.nlm.nih.gov/pubmed/26813977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.197152.115
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