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Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin
The dynorphin (Dyn) A analog zyklophin ([N-benzyl-Tyr(1)-cyclo(D-Asp(5),Dap(8))]dynorphin A(1-11)NH(2)) is a kappa opioid receptor (KOR) selective antagonist in vitro, is active in vivo and antagonizes KOR in the CNS after systemic administration. Hence, we synthesized zyklophin analogs to explore t...
Enregistré dans:
| Publié dans: | J Med Chem |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4771075/ https://ncbi.nlm.nih.gov/pubmed/26491810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501827k |
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