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Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin

The dynorphin (Dyn) A analog zyklophin ([N-benzyl-Tyr(1)-cyclo(D-Asp(5),Dap(8))]dynorphin A(1-11)NH(2)) is a kappa opioid receptor (KOR) selective antagonist in vitro, is active in vivo and antagonizes KOR in the CNS after systemic administration. Hence, we synthesized zyklophin analogs to explore t...

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Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Joshi, Anand A., Murray, Thomas F., Aldrich, Jane V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771075/
https://ncbi.nlm.nih.gov/pubmed/26491810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501827k
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