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Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin
The dynorphin (Dyn) A analog zyklophin ([N-benzyl-Tyr(1)-cyclo(D-Asp(5),Dap(8))]dynorphin A(1-11)NH(2)) is a kappa opioid receptor (KOR) selective antagonist in vitro, is active in vivo and antagonizes KOR in the CNS after systemic administration. Hence, we synthesized zyklophin analogs to explore t...
Shranjeno v:
| izdano v: | J Med Chem |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4771075/ https://ncbi.nlm.nih.gov/pubmed/26491810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501827k |
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