The Role of Biotransformation and Oxidative Stress in 3,5-Dichloroaniline (3,5-DCA) Induced Nephrotoxicity in Isolated Renal Cortical Cells from Male Fischer 344 Rats

Among the mono- and dichloroanilines, 3,5-Dichloroaniline (3,5-DCA) is the most potent nephrotoxicant in vivo and in vitro. However, the role of renal biotransformation in 3,5-DCA induced nephrotoxicity is unknown. The current study was designed to determine the in vitro nephrotoxic potential of 3,5...

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Bibliographic Details
Published in:Toxicology
Main Authors: Racine, Christopher R., Ferguson, Travis, Preston, Debbie, Ward, Dakota, Ball, John, Anestis, Dianne, Valentovic, Monica, Rankin, Gary O.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770630/
https://ncbi.nlm.nih.gov/pubmed/26808022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.01.006
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