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Unfolding the HIV-1 reverse transcriptase RNase H domain – how to lose a molecular tug-of-war
Formation of the mature HIV-1 reverse transcriptase (RT) p66/p51 heterodimer requires subunit-specific processing of the p66/p66′ homodimer precursor. Since the ribonuclease H (RH) domain contains an occult cleavage site located near its center, cleavage must occur either prior to folding or subsequ...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4770237/ https://ncbi.nlm.nih.gov/pubmed/26773054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1538 |
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