Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast carcinoma that is associated with poor patient prognosis. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed. The CXCR4-CXCL12 chemokine signaling axis guides...

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發表在:Dis Model Mech
Main Authors: Tulotta, Claudia, Stefanescu, Cristina, Beletkaia, Elena, Bussmann, Jeroen, Tarbashevich, Katsiaryna, Schmidt, Thomas, Snaar-Jagalska, B. Ewa
格式: Artigo
語言:Inglês
出版: The Company of Biologists Ltd 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770151/
https://ncbi.nlm.nih.gov/pubmed/26744352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.023275
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