Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast carcinoma that is associated with poor patient prognosis. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed. The CXCR4-CXCL12 chemokine signaling axis guides...

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Publicado en:Dis Model Mech
Autores principales: Tulotta, Claudia, Stefanescu, Cristina, Beletkaia, Elena, Bussmann, Jeroen, Tarbashevich, Katsiaryna, Schmidt, Thomas, Snaar-Jagalska, B. Ewa
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770151/
https://ncbi.nlm.nih.gov/pubmed/26744352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.023275
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