Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast carcinoma that is associated with poor patient prognosis. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed. The CXCR4-CXCL12 chemokine signaling axis guides...

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Dades bibliogràfiques
Publicat a:Dis Model Mech
Autors principals: Tulotta, Claudia, Stefanescu, Cristina, Beletkaia, Elena, Bussmann, Jeroen, Tarbashevich, Katsiaryna, Schmidt, Thomas, Snaar-Jagalska, B. Ewa
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770151/
https://ncbi.nlm.nih.gov/pubmed/26744352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.023275
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