Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer

Resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapies presents a major clinical problem. Although preclinical studies have identified a number of possible mechanisms, clinical validation has been difficult. This is most likely to reflect the reliance on cell-line models th...

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: Creedon, Helen, Balderstone, Lucy A., Muir, Morwenna, Balla, Jozef, Gomez-Cuadrado, Laura, Tracey, Natasha, Loane, Joseph, Klinowska, Teresa, Muller, William J., Brunton, Valerie G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770148/
https://ncbi.nlm.nih.gov/pubmed/26721874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.023143
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