Tolerability in man following inhalation dosing of the selective TLR7 agonist, AZD8848

BACKGROUND: Many patients with asthma have a T-helper type 2 (Th2) driven inflammation of the lung, whereas toll-like receptor 7 (TLR7) agonists, by inducing type I interferons, inhibit Th2 responses. In man, oral or parenteral TLR7 agonists can induce influenza-like symptoms through systemic induct...

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Bibliografske podrobnosti
izdano v:BMJ Open Respir Res
Main Authors: Delaney, Stephen, Biffen, Mark, Maltby, Justine, Bell, John, Asimus, Sara, Aggarwal, Ajay, Kraan, Maarten, Keeling, David
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2016
Teme:
Asthma
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769423/
https://ncbi.nlm.nih.gov/pubmed/26933507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjresp-2015-000113
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