Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid‐related orphan receptor γ agonist AZD0284

AIMS: Retinoic acid‐related orphan receptor γ (RORγ), a master regulator of T‐helper 17 (Th17) cell function and differentiation, is an attractive target for treatment of Th17‐driven diseases. This first‐in‐human study aimed to investigate the pharmacokinetics, pharmacodynamics, safety and tolerabil...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Asimus, Sara, Palmér, Robert, Albayaty, Muna, Forsman, Henrik, Lundin, Christina, Olsson, Marita, Pehrson, Rikard, Mo, John, Russell, Muir, Carlert, Sara, Close, David, Keeling, David
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319014/
https://ncbi.nlm.nih.gov/pubmed/32067249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14253
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