Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid‐related orphan receptor γ agonist AZD0284

AIMS: Retinoic acid‐related orphan receptor γ (RORγ), a master regulator of T‐helper 17 (Th17) cell function and differentiation, is an attractive target for treatment of Th17‐driven diseases. This first‐in‐human study aimed to investigate the pharmacokinetics, pharmacodynamics, safety and tolerabil...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Clin Pharmacol
Auteurs principaux: Asimus, Sara, Palmér, Robert, Albayaty, Muna, Forsman, Henrik, Lundin, Christina, Olsson, Marita, Pehrson, Rikard, Mo, John, Russell, Muir, Carlert, Sara, Close, David, Keeling, David
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319014/
https://ncbi.nlm.nih.gov/pubmed/32067249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14253
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